产品展示您现在的位置: 秒速牛牛 > 产品展示 > 抗体 > USBio抗体代理商 > 144625-HRP Rabbit Anti-EIF2AK4抗体说明

144625-HRP Rabbit Anti-EIF2AK4抗体说明


144625-HRP Rabbit Anti-EIF2AK4抗体说明
EIF2AK4(真核翻译起始因子2-Alpha激酶4),也称为GCN2,是人类中由EIF2AK4基因编码的酶。 EIF2AK4属于激酶家族,其磷酸化真核翻译起始因子-2的α亚基以响应不同的细胞应激下调蛋白质合成。

144625-HRP Rabbit Anti-EIF2AK4抗体说明



USBIo全称United States BIOLOGical,位于麻省斯万普斯科特(Swampscott, MA)。全美**的抗原抗体和生化试剂供应商,目前向全球六十余个国家的科研工作者提供约50,000种抗体、抗原和生化试剂,以质量**闻名。主要产品种类包括:抗体、生化试剂、基因克隆相关产品、培养基生长因子细胞因子、分子生物学试剂。美国US BIOLOGical公司是生物化学和生物学试剂的专业生产商,产品服务于免疫学,分子生物学,分子遗传学,体外诊断,组织培养等科研领域。产品精确度高,质量稳定,产品数量巨大,提供70,000多种抗体、抗原和生化试剂等。


uSBIo品牌144625-HRP Rabbit Anti-EIF2AK4抗体实验说明


144625-HRP Rabbit Anti-EIF2AK4 (GCN2, KIAA1338, GCN2-like protein, Eukaryotic translation initiation factor 2-alpha kinase 4) (HRP)

EIF2AK4(真核翻译起始因子2-Alpha激酶4),也称为GCN2,是人类中由EIF2AK4基因编码的酶。 EIF2AK4属于激酶家族,其磷酸化真核翻译起始因子-2的α亚基以响应不同的细胞应激下调蛋白质合成。 Hartz(2005)基于EIF2AK4序列与基因组序列的比对将EIF2AK4基因定位于染色体15q15.1。 Berlanga等。 (1999)证明从小鼠肝脏提取物免疫纯化的Gcn2可以在体外磷酸化兔Eif2。在用小鼠Eif2ak4转染的人胚肾细胞中,血清饥饿使磷酸化EIF2-α的水平增加超过2倍。 Costa-Mattioli等。 (2005)报道了来自Gcn2缺失小鼠的海马切片的独特特征:在CA1中,单个100-Hz训练诱导强烈且持续的长期增强(晚期LTP或L-LTP),其依赖于转录和翻译。 


144625-HRP Rabbit Anti-EIF2AK4抗体说明


EIF2AK4 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 4), also called GCN2, is an enzyme that in humans is encoded by the EIF2AK4 gene. EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses. Hartz (2005) mapped the EIF2AK4 gene to chromosome 15q15.1 based on an alignment of the EIF2AK4 sequence with the genomic sequence. Berlanga et al. (1999) demonstrated that Gcn2 immunopurified from mouse liver extracts could phosphorylate rabbit Eif2 in vitro. Serum starvation increased the level of phosphorylated EIF2-alpha more than 2-fold in human embryonic kidney cells transfected with mouse Eif2ak4. Costa-Mattioli et al. (2005) reported a unique feature of hippocampal slices from Gcn2-null mice: in CA1, a single 100-Hz train induced a strong and sustained long-term potentiation (late LTP or L-LTP), which was dependent on transcription and translation.


Suitable for use in Western Blot。 Other applications not tested。

Recommended Dilutions

Western Blot: 0.1-0.5ug/ml. The detection limit for EIF2AK4 is ~0.5ng/lane under reducing conditions. Optimal dilutions to be determined by the researcher.

Storage and StABIlity

Lyophilized powder may be stored at -20°C。 Stable for 12 months after receipt at -20°C。 Reconstitute with sterile ddH2O。 Aliquot to avoid repeated freezing and thawing。 Store at -20°C。 For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap。 Further dilutions can be made in assay buffer。

Note: Applications are based on unconjugated antibody。


Synthetic peptide corresponding aa870-888, ATDHLAFSADSKQDDQTGD in the middle region of human EIF2AK4 (Q9P2K8)


Supplied as a liquid in PBS, pH 7.2. Labeled with horserADIsh peroxidase (HRP).


Purified by immunoaffinity chromatography。


Recognizes human h。EIF2AK4。 No crossreactivity with other proteins。



144325-HRPAnti-CD44 (MDU2, MDU3, MIC4, CD44R, CDw44, IN, HUTCH-I, CSPG8, HCELL, MC56, Pgp1, Epican, LHR, PGP-1, PGP-I, ECMR-III, Hyaluronate receptor, Heparan sulfate proteoglycan, Phagocytic glycoprotein 1, Phagocytic glycoprotein I, chondroitin sulfate proteoglycan 8, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, hematopoietic cell E- and L-selectin ligand, CD44 antigen homing function and Indian blood group system) (HRP)
PabrabbithumanIgG Hu,RtHRP$628  
  CD44  IC,IHC100ul  
144571-HRPAnti-GH (GHN, GH, GH-N, hGH-N, Growth hormone, pituitary growth hormone) (HRP)
PabrabbithumanIgG HuHRP$592  
  GH1  E,IHC,WB100ul  
144625-HRPAnti-EIF2AK4 (GCN2, KIAA1338, GCN2-like protein, Eukaryotic translation initiation factor 2-alpha kinase 4) (HRP)
PabrabbithumanIgG HuHRP$628  
  EIF2AK4  WB100ul  
144734-HRPAnti-IL-17/IL-17A (Cytotoxic T-lymphocyte-associated antigen 8) (HRP)
PabrabbitmouseIgG MoHRP$592  
  IL17A  E,WB100ul  
144773-HRPAnti-Interleukin-7 (IL-7) (HRP)
PabrabbithumanIgG HuHRP$592  
  IL7  E,WB100ul  
144853-HRPAnti-KLK1 (m.KLK1, Klk-6, Klk6, mGK-6, Glandular kallikrein K1, KAL-B, KLKR, Renal kallikrein, Tissue kallikrein-6) (HRP)
PabrabbitmouseIgG MoHRP$628  
  KLK1  IHC,WB100ul  
145210-HRPAnti-SP-A (35kD pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-4) (HRP)
PabrabbithumanIgG Hu,RtHRP$628  
  SFTPA1  WB100ul  
303194-HRPAnti-CCL3 (C C Motif Chemokine 3, CCL 3, CCL3_HUMAN, Chemokine C C Motif Ligand 3, Chemokine CC Motif Ligand 3, G0/G1 Switch Regulatory Protein 19 1, G0/G1 Switch Regulatory Protein 19-1, G0S19 1, G0S19 1 Protein, Heparin Binding Chemotaxis Protein, L2G25B, LD78 alpha, LD78-alpha(4-69), LD78ALPHA, Macrophage Inflammatory Protein 1 alpha, Macrophage Inflammatory Protein 1-alpha, MIP 1 alpha, MIP 1A, MIP-1-alpha, MIP-1-alpha(4-69), MIP1A, PAT 464.1, SCYA 3, SCYA3, SIS alpha, SIS beta, SIS-beta, Small InducIBLe Cytokine A3, Small-inducIBLe Cytokine A3, Tonsillar Lymphocyte LD78 alpha Protein) (HRP)
PabrabbitratIgG RtHRP$592 
303591-HRPAnti-Serum Amyloid P (9.5S alpha 1 Glycoprotein, 9.5S alpha-1-glycoprotein, Amyloid P Component Serum, APCS, Pentaxin Related, Pentraxin 2, PTX 2, PTX2, SAMP_HUMAN, SAP, Serum Amyloid P Component, Serum Amyloid P-component(1-203)) (HRP)
PabrabbitmouseIgG MoHRP$592 
303592-HRPAnti-Serum Amyloid P (9.5S alpha 1 Glycoprotein, 9.5S alpha-1-glycoprotein, Amyloid P Component Serum, APCS, Pentaxin Related, Pentraxin 2, PTX 2, PTX2, SAMP_HUMAN, SAP, Serum Amyloid P Component, Serum Amyloid P-component(1-203)) (HRP)
PabrabbitratIgG RtHRP$592 
144134-PEAnti-ADIPOQ (ACDC, ADPN, apM-1, APM1, ACRP30, ADIponectin, GBP28, ADIponectin precursor, Gelatin-binding protein, GELATIN-BINDING PROTEIN, 28-KD, ADIPOCYTE-SPECIFIC SECRETORY PROTEIN, 30kD ADIpocyte complement-related protein, ADIpocyte complement-related 30kD protein, ADIpose most abundant gene transcript 1, ADIpose most abundant gene transcript 1 protein, adipocyte, C1Q and collagen domain containing, Adipocyte, C1q and collagen domain-containing protein) (PE)
PabrabbithumanIgG Hu,Mo,RtPE$628  
  ADIPOQ  E,IHC,WB100ul  
144198-PEAnti-ARG1 (Liver-type arginase, Type I arginase) (PE)
PabrabbitratIgG RtPE$628  
  ARG1  WB100ul  
144320-PEAnti-CD40 (B Cell surface antigen CD40, Bp50, CD40L receptor, CD_antigen CD40) (PE)
PabrabbitmouseIgG MoPE$628  
  CD40  WB100ul  
144360-PEAnti-CEA (Carcinoembryonic antigen) (PE)
PabrabbithumanIgG HuPE$592  
  CEACAM5  E,IHC,WB100ul  
144402-PEAnti-Cullin3 (Cullin-3, Cul 3) (PE)
PabrabbithumanIgG Hu,RtPE$628  
  CUL3  WB100ul


  • 产品:

  • 留言内容:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 详细地址:

  • 省份:

  • 验证码: